Ngexesha lokufunda, abaphandi bafumanise ukuba kwizigulana ezifumene i-CBD, zombini ixhala kunye neenyikima-uphawu oluqhelekileyo lweParkinson's olunokuthi lwandiswe ngoxinzelelo-lwancitshiswa.UGuillaume Payen / Imifanekiso ye-SOPA / i-LightRocket nge-Getty Izithombe Glossophobia , uloyiko lokuthetha esidlangalaleni-kwaye ubeke ubuntu bakho, iinkqubo zokucinga kunye nokuzithemba kwakho ekujongeni okutshisayo kwindawo yentengiso yeembono-sisifo esiqhelekileyo esaneleyo esinokunyangwa ngamanyathelo okungenelela amayeza kunye panoply of hack hack .
Eyona nto isebenzayo kunokufanekisela abaphulaphuli bakho bekwiimeko zokungakhathali yonyango lokuziphatha, okanye unyango lokulwa nexhala, okanye-kuba le yi-2020- uthini malunga ne-CBD ethile? Ithamo elikhulu lamafutha CBD Kuya kufuneka uphelise izikhalazo zakho kakuhle, isifundo esitsha esivela eBrazil sicebisa . Nangona kunjalo, kukho enye i-caatat enkulu: Iziphumo zikhawulelwe kwizigulana ezinesifo sika-Parkinson-oko kuthetha ukuba iziphumo zinokubaluleka kokubini ukuba sinyangwa njani eso sifo kunye nokuqonda indlela i-CBD esebenza ngayo kwingqondo.
Njengoko kuchaziwe kwi inqaku elipapashwe kwi Ijenali yePsychopharmacology , Abaphandi kwiFederal University yaseSão Carlos kunye neDyunivesithi yaseSão Paulo bafaka abantu abangama-24 kuvavanyo olwahlukileyo lokuthetha esidlangalaleni, ngaphandle kweentsuku ezili-15. Amashumi amabini anesibini kwezi zigulana ezingama-24 yayingamadoda, kwaye uninzi lwalukwamanye amayeza, aqhelekileyo i-levodopa.
Ngalo lonke ixesha, isiqingatha sasinikwa i-300 milligram ye-CBD, esinye isiqingatha se-placebo. (Ngexesha elilandelayo ukuphuma, i-placebo-receiver zaye zanikwa i-CBD, kwaye ngokuchaseneyo.) Izifundo zovavanyo zazinenqanaba lentliziyo, uxinzelelo lwegazi kunye nokuhamba kweenyikima.
Kwaye kwizigulana ezifumene i-CBD, zombini ixhala kunye nokungcangcazela-uphawu oluqhelekileyo lweParkinson's olunokuthi lwandiswe ngoxinzelelo-lwancitshiswa.
Olu phononongo lubonisa ukuba i-CBD inokuba lolunye unyango kwizigulana ezine- [Parkinson’s] kunye noxinzelelo, babhala abaphandi. Ke, ulawulo olungapheliyo lwe-CBD lunokuvavanywa kwizifundo ezizayo.
Kwabanye, ubudoda besifundo bunokuba yingxaki, kodwa i-caveat ekhankanywe ngasentla ivela kwinto yokuba izifundo zophando ezingama-24 kolu phononongo zonke zaphathwa sisifo sika-Parkinson-sisifo esibi kakhulu kodwa esinqabileyo esichaphazela i-3.3% yabantu abadala abangama-64 nangaphezulu. Kutheni umda kwisifundo sophando ngale ndlela?
Ixhala kunye nokungcangcazela kwabalindi kuhlasela i-67% yezigulana zika-Parkinson-kwaye eyona njongo iphambili kolu phando yayikukwakha uphando lwangaphambili kunye nokufumanisa ukuba ngaba i-CBD ikwenzile na ukuzola ukungcangcazela kunye neempawu ezizezona zoxinzelelo.
Ilungile lonto. Kwakhona kubalulekile, kwaye kusebenza ngokubanzi, ukuqonda indima yenkqubo ye-endocannabinoid kuzo zombini iingxaki zokuxhalaba kunye ne-Parkinson.
Njengoko abaphandi beqaphele, esi sifo sihlala sinyangwa ngamayeza amayeza aneziphumo ebezingalindelekanga ezibandakanya ukungcangcazela, ukungakwazi ukuqonda kunye nokwanda komngcipheko wokuwa.
Ukufumana olunye unyango kumachiza amayeza kunye neziphumo ebezingalunganga ziya kongeza ixabiso-kunye nokufumanisa naluphi na unxibelelwano phakathi kweempawu ezinciphileyo kunye ne-endocannabinoid receptors. Olunye uphando lubonisa ukuba i-CBD inciphisa ukudumba ebuchotsheni kwaye iyayandisa i-neuroplasticity, yiyo loo nto inceda ukusebenza kwengqondo (kwaye, ngokunokwenzeka, ukunyanga iimpawu ze-Alzheimer's). Ngaba i-CBD izolile iinyikima ngenxa yokuthomalalisa uxinzelelo, okanye ngaba ikwenzile enye into kulawulo lomzimba?
Impendulo emfutshane kukuba asiqinisekanga okwangoku. Inkqubo ye-endocannabinoid , khumbula, yinethiwekhi yee-receptors kwingqondo nasemzimbeni othumela kunye nokufumana imiqondiso ethi yona ilawule imisebenzi ephambili kubandakanya imood, ukuthanda ukutya, ukulala kunye nememori. Nokuba i-CBD ingaba naziphi na iimpembelelo kwiimpawu zeemoto ezibangelwa luxinzelelo yayiyinto entsha yesifundo, njengoko babebhala abaphandi. Kwaye ngelixa kungekho datha yaneleyo yokubeka nantoni na eqinisekileyo, abaphandi bacebise ukuba ubukho be-CBD bunokunciphisa umsebenzi kwi-receptor enye, i-5-HT1A, ezinokuthi zithintele iinyikima.
Okwangoku, akunakwenzeka ukugqiba ukuba ngaba i-CBD inefuthe ngqo kubungakanani beenyikima okanye ukuba ukuncitshiswa kwamanqanaba oxinzelelo kukhokelele kwiyantlukwano ebonwayo, abaphandi babhala.
Nangona kunjalo, isibonelelo esivela kwichiza elineziphumo ebezingalindelekanga kwizigulana ezineParkinson's, kunye neempawu zokuqala zokuba i-CBD inokubangela imisebenzi ebuchotsheni yokunciphisa iimpawu zoxinzelelo njengokungcangcazela, kubonakala ngathi kungaphezulu kokuthethelela isifundo-kunye nophando lwe-CBD lwexesha elizayo, uninzi lwayo luyeza ngokuqinisekileyo.
